Body posture could affect the efficiency of drugs
Concerning this, researchers from Johns Hopkins University and Johns Hopkins School of Medicine have conducted a study to examine how body posture and stomach motility affect drug bioavailability. They used a biomimetic in-silico simulator based on the realistic anatomy and morphology of the stomach called a "StomachSim," according to the press release.
"Oral administration is surprisingly complex despite being the most common choice for drug administration," said Rajat Mittal, the co-author of the study. "When the pill reaches the stomach, the motion of the stomach walls and the flow of contents inside determine the rate at which it dissolves. The properties of the pill and the stomach contents also play a major role."
"However, current experimental or clinical procedures for assessing the dissolution of oral drugs are limited in their ability to study this, which makes it a challenge to understand how the dissolution is affected in different stomach disorders, such as gastroparesis, which slows down the emptying of the stomach."
Diagram showing the original position of the stomach.
Stomach contents, motility, and gastric fluid dynamics are also influential factors in a drug's bioavailability. In addition to that, stomach contractions can create pressure and cause complex pill trajectories. This leads to varying rates of pill dissolutiın and nonuniform emptying of the drug into the duodenum (the first part of the small intestine), and even gastric dumping in the case of modified-release dosage. All of these provide various difficulties for the design of drug delivery.